Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26640963 | 1.00 | STAT6 (0.42) | STAT6MAPTGRM5TP53IGF1R | |
| SCHEMBL26640962 | 0.82 | AURKA (0.50) | STAT6MAPTGRM5TP53IGF1R | |
| SCHEMBL26640771 | 0.81 | GRM5 (0.50) | MAPTGRM5TP53CDK5CDK5R1 | |
| SCHEMBL26640349 | 0.79 | AXL (0.51) | MAPTGRM5TP53IGF1RCDK5 | |
| SCHEMBL26640878 | 0.79 | GRM5 (0.47) | STAT6MAPTGRM5TP53CDK5 | |
| SCHEMBL27054171 | 0.77 | CDK5 (0.49) | MAPTGRM5TP53CDK5CDK5R1 | |
| SCHEMBL26640426 | 0.76 | CDK5 (0.46) | MAPTGRM5TP53IGF1RCDK5 | |
| SCHEMBL30648661 | 0.76 | CDK5 (0.46) | MAPTGRM5TP53IGF1RCDK5 | |
| SCHEMBL26640788 | 0.76 | GRM5 (0.45) | MAPTGRM5TP53CDK5CDK5R1 | |
| SCHEMBL30648703 | 0.76 | CDK5 (0.48) | STAT6GRM5CDK5CDK5R1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |