Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 12/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033270 | 1.00 | MAPT (0.57) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26640119 | 0.96 | MAPT (0.61) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26640120 | 0.90 | MAPT (0.57) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26640686 | 0.87 | MAPT (0.57) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26640906 | 0.86 | MAPT (0.62) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26641038 | 0.85 | MAPT (0.61) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26640907 | 0.84 | MAPT (0.70) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26640184 | 0.83 | MAPT (0.60) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL26640688 | 0.83 | MAPT (0.66) | MAPTMAPK1PDGFRBDDB1CRBN | |
| SCHEMBL30648793 | 0.82 | MAPT (0.40) | MAPTMAPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |