Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.58 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29697528 | 0.92 | TRIM24 (0.61) | TRIM24TRIM33ALDH1A1CRBNFKBP5 | |
| SCHEMBL29121518 | 0.90 | TRIM24 (0.52) | TRIM24TRIM33ALDH1A1CRBNFKBP5 | |
| SCHEMBL1463457 | 0.89 | — | — | |
| SCHEMBL583821 | 0.83 | — | — | |
| SCHEMBL31451830 | 0.82 | TRIM24 (0.48) | TRIM24TRIM33ALDH1A1CRBNFKBP5 | |
| SCHEMBL22319260 | 0.79 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1CRBNFKBP5 | |
| SCHEMBL22319288 | 0.79 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1CRBNFKBP5 | |
| SCHEMBL22319285 | 0.79 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1CRBNFKBP5 | |
| SCHEMBL12857131 | 0.79 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1CRBNFKBP5 | |
| SCHEMBL22319261 | 0.79 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1CRBNFKBP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024230807-A1 | PYRIMIDO MACROHETEROCYCLIC COMPOUND AS WEE1-YES DUAL-TARGET INHIBITOR AND USE THEREOF | 杭州德睿智药科技有限公司 | 2024-11-14 | — | — | WO | disclosed |
| WO-2023217201-A2 | NOVEL PYRIMIDO-HETEROCYCLIC NOVEL COMPOUND SERVING AS WEE1 INHIBITOR AND APPLICATION THEREOF | 杭州德睿智药科技有限公司 | 2023-11-16 | — | — | WO | disclosed |