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Sugi Predict / Compounds / SCHEMBL30658032

SCHEMBL30658032

SCHEMBL30658032

Cc1ncsc1-c1ccc([C@H](C)NC(=O)C2CC(O)CN2C(=O)[C@@H](c2cc(N3CC4(CC(c5cc6nnc(-c7ccccc7O)cc6n5C5CCC5)C4)C3)no2)C(C)C)cc1

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ VHL P40337 18/20 0.56
▸ SMARCA2 P51531 4/20 0.53
▸ SMARCA4 P51532 4/20 0.53
▸ ELOC Q15369 2/20 0.38
▸ ELOB Q15370 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31589099 1.00 VHL (0.56) VHLSMARCA2SMARCA4ELOCELOB
SCHEMBL26804537 0.93 VHL (0.58) VHLSMARCA2SMARCA4
SCHEMBL26653883 0.91 VHL (0.43) VHLSMARCA2SMARCA4ELOCELOB
SCHEMBL26653886 0.91 VHL (0.43) VHLSMARCA2SMARCA4ELOCELOB
SCHEMBL26794220 0.87 VHL (0.56) VHLSMARCA2SMARCA4
SCHEMBL31294097 0.86 VHL (0.58) VHLSMARCA2SMARCA4ELOCELOB
SCHEMBL31294108 0.86 VHL (0.62) VHLSMARCA2SMARCA4ELOCELOB
SCHEMBL31294105 0.86 VHL (0.62) VHLSMARCA2SMARCA4ELOCELOB
SCHEMBL30666227 0.86 VHL (0.59) VHLSMARCA2SMARCA4ELOCELOB
SCHEMBL30666268 0.86 VHL (0.59) VHLSMARCA2SMARCA4ELOCELOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4522279-A1 PYRAZINE DERIVATIVES AND USES THEREOF Foghorn Therapeutics Inc. (US) 2025-03-19 — — EP disclosed
WO-2023220134-A1 PYRAZINE DERIVATIVES AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2023-11-16 — — WO disclosed
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