Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.49 |
| ▸ | JAK2 | O60674 | 19/20 | 0.49 |
| ▸ | JAK1 | P23458 | 19/20 | 0.49 |
| ▸ | JAK3 | P52333 | 17/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29127251 | 1.00 | TYK2 (0.49) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL30664034 | 0.83 | JAK2 (0.54) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL29127271 | 0.83 | JAK2 (0.54) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL29127275 | 0.83 | TYK2 (0.56) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL30664047 | 0.83 | TYK2 (0.56) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL18894251 | 0.83 | JAK2 (0.67) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL30664061 | 0.83 | JAK2 (0.67) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL12280052 | 0.82 | JAK3 (0.44) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL2337440 | 0.81 | TYK2 (0.55) | TYK2JAK2JAK1JAK3MAP4K4 | |
| SCHEMBL29127165 | 0.81 | JAK1 (0.50) | TYK2JAK2JAK1JAK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116924976-A | Diaryl heterocyclic amine compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2023-10-24 | — | — | CN | disclosed |