Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 14/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HAT1 | O14929 | 1/20 | 0.51 |
| ▸ | EP300 | Q09472 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18115988 | 1.00 | USP30 (0.57) | USP30GSK3BDYRK1AAXLKDM4E | |
| SCHEMBL16532592 | 0.79 | MAPT (0.49) | GSK3BDYRK1AKDM4ESTAT3HIF1A | |
| SCHEMBL19998606 | 0.77 | AXL (0.65) | USP30GSK3BDYRK1AAXL | |
| SCHEMBL28369895 | 0.77 | AXL (0.65) | GSK3BDYRK1AAXL | |
| SCHEMBL30269963 | 0.77 | AXL (0.65) | GSK3BDYRK1AAXL | |
| SCHEMBL16516847 | 0.77 | GSK3B (0.53) | GSK3BDYRK1A | |
| SCHEMBL3387378 | 0.76 | PDPK1 (0.60) | GSK3BDYRK1AKDM4ESTAT3HIF1A | |
| SCHEMBL26119042 | 0.75 | TTK (0.47) | — | |
| SCHEMBL12788089 | 0.74 | KDM4E (0.65) | KDM4ESTAT3HIF1A | |
| SCHEMBL18115925 | 0.74 | USP30 (1.00) | USP30GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112707893-B | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2023-10-31 | — | — | CN | disclosed |