SCHEMBL30669253

SCHEMBL30669253

O=C1N[C@@H](c2cccc(C#Cc3ccccc3)c2)[C@H](c2ccccc2)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 20/20 1.00
PGR P06401 1/20 0.52
KCNH2 Q12809 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13641797 1.00 GRM5 (1.00) GRM5PGRKCNH2
SCHEMBL4539140 1.00 GRM5 (1.00) GRM5PGRKCNH2
SCHEMBL4538338 1.00 GRM5 (1.00) GRM5PGRKCNH2
SCHEMBL4542930 1.00 GRM5 (1.00) GRM5PGRKCNH2
SCHEMBL4534817 1.00 GRM5 (1.00) GRM5PGRKCNH2
SCHEMBL4537462 1.00 GRM5 (1.00) GRM5PGRKCNH2
SCHEMBL4534815 1.00 GRM5 (1.00) GRM5PGRKCNH2
SCHEMBL4561961 0.92 GRM5 (0.85) GRM5
SCHEMBL13640442 0.92 GRM5 (0.85) GRM5
SCHEMBL4562459 0.92 GRM5 (0.85) GRM5PGRKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE49735-E1 Oxazolidinones as modulators of MGLUR5 BRISTOL-MYERS SQUIBB COMPANY (US) 2023-11-28 US disclosed