Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.62 |
| ▸ | JAK3 | P52333 | 3/20 | 0.62 |
| ▸ | ITK | Q08881 | 8/20 | 0.54 |
| ▸ | EGFR | P00533 | 14/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | BLK | P51451 | 2/20 | 0.52 |
| ▸ | BMX | P51813 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.52 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.52 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.52 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.52 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16391117 | 1.00 | BTK (0.62) | BTKJAK3ITKEGFRMAPK3 | |
| SCHEMBL16706353 | 0.94 | BTK (0.63) | BTKJAK3ITKEGFRMAPK3 | |
| SCHEMBL16391110 | 0.87 | JAK3 (0.63) | BTKJAK3ITKEGFRJAK2 | |
| SCHEMBL30672898 | 0.86 | BTK (0.65) | BTKJAK3ITKEGFRJAK2 | |
| SCHEMBL16370912 | 0.86 | BTK (0.65) | BTKJAK3ITKEGFRJAK2 | |
| SCHEMBL16706326 | 0.82 | JAK3 (0.64) | BTKJAK3ITKEGFRJAK2 | |
| SCHEMBL16371034 | 0.81 | BTK (0.59) | BTKJAK3ITKEGFR | |
| SCHEMBL30672759 | 0.81 | BTK (0.59) | BTKJAK3ITKEGFR | |
| SCHEMBL16391124 | 0.81 | BTK (0.65) | BTKJAK3ITKEGFRJAK2 | |
| SCHEMBL16371031 | 0.81 | EGFR (0.68) | BTKJAK3ITKEGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117486865-A | Pyrimidine derivatives as kinase inhibitors | 艾森医药公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-112592334-B | Pyrimidine derivatives as kinase inhibitors | 艾森医药公司 | 2023-10-27 | — | — | CN | disclosed |