Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697747 | 0.83 | MEN1 (0.72) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL11309467 | 0.83 | MEN1 (0.72) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL11309469 | 0.83 | MEN1 (0.72) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL11308988 | 0.83 | MEN1 (0.72) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL14705767 | 0.82 | MAPT (0.55) | MAPTKMT2AMEN1NPSR1LMNA | |
| Hydrochloric Acid SCHEMBL28148117 | 0.82 | MEN1 (0.70) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL30930812 | 0.82 | KMT2A (0.53) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL30673562 | 0.82 | MAPT (0.46) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL8388743 | 0.82 | MAPT (0.49) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL7071032 | 0.81 | NPSR1 (0.55) | MAPTKMT2AMEN1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250353844-A1 | TETRAHYDROPYRIDO 3,4-D PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2025-11-20 | — | — | US | disclosed |
| EP-4536659-A1 | TETRAHYDROPYRIDO 3,4-D PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | Bristol-Myers Squibb Company (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119317629-A | Tetrahydropyrido 3,4-D pyrimidine derivatives as KRAS inhibitors | 百时美施贵宝公司 | 2025-01-14 | — | — | CN | disclosed |
| WO-2023240189-A1 | TETRAHYDROPYRIDO 3,4-D PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250353844-A1 | TETRAHYDROPYRIDO 3,4-D PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | KRAS, NRAS, HRAS | MAPT 4293/4885KMT2A 2034/4885MEN1 2399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.