Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23100852 | 1.00 | PTPN11 (0.58) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23100844 | 0.90 | PTPN11 (0.69) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL30809748 | 0.90 | PTPN11 (0.69) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23063963 | 0.89 | PTPN11 (0.71) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23063942 | 0.88 | PTPN11 (0.70) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL30677217 | 0.88 | PTPN11 (0.71) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23064049 | 0.88 | PTPN11 (0.71) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23126447 | 0.87 | PTPN11 (0.72) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23064013 | 0.87 | PTPN11 (0.72) | PTPN11 | |
| SCHEMBL23064024 | 0.87 | PTPN11 (0.72) | PTPN11KCNH2MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112351780-B | Substituted heterocyclic inhibitors of PTPN11 | 纳维尔制药有限公司 | 2023-12-01 | — | — | CN | disclosed |