Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29847854 | 0.87 | MAPT (0.76) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL16513593 | 0.87 | MAPT (0.76) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL23525556 | 0.83 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL22652238 | 0.83 | MAPT (0.76) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL3925665 | 0.83 | MAPT (0.71) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4365700 | 0.82 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL23525546 | 0.82 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL30020102 | 0.82 | MAPT (0.69) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL23293826 | 0.81 | MAPT (0.67) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL8221482 | 0.80 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116981664-A | Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of NUAK kinase, compositions and uses thereof | 安大略省癌症研究所(OICR) | 2023-10-31 | — | — | CN | disclosed |