Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPA | P23025 | 17/20 | 0.85 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | APEX1 | P27695 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.69 |
| ▸ | GALK1 | P51570 | 1/20 | 0.69 |
| ▸ | EP300 | Q09472 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29385593 | 0.94 | XPA (0.85) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL19654076 | 0.94 | XPA (0.85) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL22205249 | 0.92 | XPA (1.00) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL19644342 | 0.92 | XPA (1.00) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL19644341 | 0.92 | XPA (1.00) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL19654082 | 0.87 | XPA (0.81) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL22463080 | 0.87 | XPA (0.81) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL19644175 | 0.87 | XPA (1.00) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL19644173 | 0.87 | XPA (1.00) | XPAMEN1APEX1KMT2ANTSR1 | |
| SCHEMBL19644185 | 0.87 | XPA (1.00) | XPAMEN1APEX1KMT2ANTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684354-B1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | UNIV INDIANA RES & TECH CORP (US) | 2023-11-15 | — | — | EP | disclosed |