SCHEMBL30680842

SCHEMBL30680842

COc1cc(Cn2cccn2)cc2onc(NS(=O)(=O)c3cccc(N4CCC(N)CC4)c3)c12

nearest known ligand 0.72

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT7 O95251 20/20 0.72
▸ KAT6A Q92794 20/20 0.72
▸ KAT6B Q8WYB5 10/20 0.71
▸ KAT5 Q92993 10/20 0.71
▸ KAT8 Q9H7Z6 10/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26969673 1.00 KAT7 (0.72) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680822 0.90 KAT7 (0.74) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26969652 0.90 KAT7 (0.74) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26969647 0.90 KAT7 (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680850 0.89 KAT7 (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26969636 0.89 KAT7 (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26969634 0.89 KAT7 (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680828 0.89 KAT7 (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680848 0.89 KAT7 (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680836 0.87 KAT7 (0.63) KAT7KAT6AKAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4539937-A1 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY Prelude Therapeutics Incorporated (US) 2025-04-23 — — EP disclosed
WO-2023245150-A9 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY PRELUDE THERAPEUTICS INCORPORATED (US) 2025-01-16 — — WO disclosed
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