Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.76 |
| ▸ | PKM | P14618 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073750 | 0.88 | SCN3A (0.64) | SCN3APKMALDH1A1LMNAKDM4E | |
| SCHEMBL26530281 | 0.88 | SCN3A (0.71) | SCN3APKMALDH1A1LMNAKDM4E | |
| SCHEMBL3063552 | 0.88 | SCN3A (0.59) | SCN3ASCN9ASCN5A | |
| SCHEMBL3060426 | 0.86 | SCN3A (1.00) | SCN3APKMALDH1A1LMNAKDM4E | |
| SCHEMBL3066948 | 0.85 | SCN3A (0.66) | SCN3APKMALDH1A1SCN9ASCN5A | |
| SCHEMBL3073248 | 0.85 | SCN3A (0.66) | SCN3APKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3060376 | 0.84 | SCN3A (0.70) | SCN3APKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3063891 | 0.84 | SCN3A (0.65) | SCN3APKMALDH1A1LMNAKDM4E | |
| SCHEMBL16273104 | 0.82 | SCN3A (0.74) | SCN3APKMALDH1A1LMNAKDM4E | |
| SCHEMBL3061126 | 0.82 | SCN3A (0.73) | SCN3APKMALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357685-A1 | Sodium Channel Inhibitors | ICAGEN INC (US) | 2014-12-04 | — | — | US | disclosed |
| US-8853250-B2 | Sodium channel inhibitors | ICAGEN, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2175728-B1 | SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2014-09-10 | — | — | EP | disclosed |
| US-20100267782-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC (US) | 2010-10-21 | — | — | US | disclosed |
| EP-2175728-A1 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009012241-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357685-A1 | Sodium Channel Inhibitors | TRPV1, SCN1A, SCN2A | SCN3A 8/4885PKM 2661/4885ALDH1A1 2837/4885 |
| US-20100267782-A1 | SODIUM CHANNEL INHIBITORS | TRPV1, SCN1A, SCN2A | SCN3A 8/4885PKM 2661/4885ALDH1A1 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.