Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.70 |
| ▸ | AKT2 | P31751 | 3/20 | 0.70 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30682819 | 1.00 | AKT1 (0.70) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL26957714 | 1.00 | AKT1 (0.70) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL25359156 | 0.93 | AKT1 (0.77) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL26137117 | 0.93 | AKT1 (0.77) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30590246 | 0.93 | AKT1 (0.77) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30682831 | 0.92 | AKT1 (0.59) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL26125085 | 0.92 | AKT1 (0.65) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL26137119 | 0.91 | AKT1 (0.72) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL26128324 | 0.91 | AKT1 (0.72) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30682800 | 0.90 | AKT1 (0.69) | AKT1AKT2AKT3PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4536643-A1 | BENZOPYRIMIDIN-4(3H)-ONES AS PI3K INHIBITORS | OnKure, Inc. (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119744260-A | Benzopyrimidin-4 (3H) -ones as PI3K inhibitors | 恩库勒公司 | 2025-04-01 | — | — | CN | disclosed |
| WO-2023239710-A1 | BENZOPYRIMIDIN-4(3H)-ONES AS PI3K INHIBITORS | ONKURE, INC. (US) | 2023-12-14 | — | — | WO | disclosed |