Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.93 |
| ▸ | MET | P08581 | 11/20 | 0.93 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.93 |
| ▸ | KDR | P35968 | 4/20 | 0.93 |
| ▸ | MERTK | Q12866 | 3/20 | 0.93 |
| ▸ | FLT1 | P17948 | 3/20 | 0.93 |
| ▸ | FLT3 | P36888 | 2/20 | 0.93 |
| ▸ | AURKA | O14965 | 1/20 | 0.93 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.93 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.93 |
| ▸ | ABL1 | P00519 | 1/20 | 0.93 |
| ▸ | EGFR | P00533 | 1/20 | 0.93 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.93 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.93 |
| ▸ | LCK | P06239 | 1/20 | 0.93 |
| ▸ | PGR | P06401 | 1/20 | 0.93 |
| ▸ | LYN | P07948 | 1/20 | 0.93 |
| ▸ | RET | P07949 | 1/20 | 0.93 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.93 |
| ▸ | HCK | P08631 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cabozantinib SCHEMBL29351408 | 0.96 | AXL (1.00) | AXLMETAURKBKDRMERTK | |
| Cabozantinib SCHEMBL29728791 | 0.96 | AXL (1.00) | AXLMETAURKBKDRMERTK | |
| Cabozantinib SCHEMBL360795 | 0.96 | AXL (1.00) | AXLMETAURKBKDRMERTK | |
| Cabozantinib SCHEMBL18095042 | 0.95 | AXL (0.98) | AXLMETAURKBKDRMERTK | |
| Cabozantinib SCHEMBL18097906 | 0.94 | AXL (0.94) | AXLMETAURKBKDRMERTK | |
| Cabozantinib SCHEMBL18095040 | 0.93 | AXL (0.93) | AXLMETAURKBKDRMERTK | |
| Cabozantinib SCHEMBL29195419 | 0.92 | AXL (0.91) | AXLMETAURKBKDRMERTK | |
| SCHEMBL15872120 | 0.91 | AXL (0.90) | AXLMETAURKBKDRMERTK | |
| SCHEMBL30918289 | 0.91 | AXL (0.90) | AXLMETAURKBKDRMERTK | |
| Cabozantinib SCHEMBL18097904 | 0.91 | AXL (0.90) | AXLMETAURKBKDRMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120447-A | Cyclic compounds and methods of use thereof | 薛定谔公司 | 2023-11-24 | — | — | CN | disclosed |