⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30696121 | 1.00 | — | — | |
| SCHEMBL30696127 | 0.80 | — | — | |
| SCHEMBL10189545 | 0.75 | — | — | |
| SCHEMBL30985508 | 0.71 | — | — | |
| SCHEMBL30918095 | 0.71 | — | — | |
| SCHEMBL30918116 | 0.71 | — | — | |
| SCHEMBL30918070 | 0.71 | — | — | |
| SCHEMBL30985755 | 0.71 | — | — | |
| SCHEMBL30918111 | 0.71 | — | — | |
| SCHEMBL30918120 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119894891-A | KRAS G12D inhibitor and application thereof | 上海和誉生物医药科技有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119677749-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-118772176-A | Pyrimidine aromatic ring compound and preparation method and application thereof | 四川汇宇制药股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-118660880-A | Quinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-118556063-A | Heterocyclic compound, pharmaceutical composition and application thereof | 上海湃隆生物科技有限公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-117255684-A | Quinazolinamine derivatives as KRAS inhibitors | 尼坎治疗公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-117222650-A | Pyridine or pyrimido-ring compound, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2023-12-12 | — | — | CN | disclosed |