Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 6/20 | 0.60 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493105 | 1.00 | NPC1 (0.64) | NPC1NR4A2PBRM1CREBBPKIF11 | |
| SCHEMBL6418495 | 0.91 | NR4A2 (0.72) | NPC1NR4A2CREBBPKIF11ASH1L | |
| SCHEMBL30899481 | 0.89 | NPC1 (0.66) | NPC1NR4A2CREBBPKIF11ASH1L | |
| SCHEMBL4780495 | 0.89 | NPC1 (0.66) | NPC1NR4A2CREBBPKIF11ASH1L | |
| SCHEMBL3931730 | 0.88 | NR4A2 (0.60) | NPC1NR4A2PBRM1CREBBPMEN1 | |
| SCHEMBL10397736 | 0.88 | NR4A2 (0.68) | NPC1NR4A2PBRM1CREBBPKIF11 | |
| SCHEMBL4164843 | 0.87 | NPC1 (0.63) | NPC1NR4A2CREBBPKIF11ASH1L | |
| SCHEMBL6417880 | 0.85 | PBRM1 (0.61) | NPC1NR4A2PBRM1KIF11MEN1 | |
| SCHEMBL6332786 | 0.85 | NPC1 (0.61) | NPC1NR4A2CREBBPKIF11ASH1L | |
| SCHEMBL695111 | 0.85 | NPC1 (0.57) | NPC1NR4A2CREBBPKIF11ASH1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217967-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-07-04 | — | — | US | disclosed |
| CN-117062812-A | Indoline derivatives as DDR inhibitors | 奇斯药制品公司 | 2023-11-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217967-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | DDR1, DDR2, DDRGK1 | NPC1 3820/4885NR4A2 1190/4885PBRM1 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.