Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.50 |
| ▸ | NRAS | P01111 | 9/20 | 0.50 |
| ▸ | CDK7 | P50613 | 4/20 | 0.37 |
| ▸ | CCNH | P51946 | 4/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 2/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000141 | 0.90 | CDK7 (0.45) | FLT3NRASCDK7CCNHMNAT1 | |
| SCHEMBL31739788 | 0.89 | NRAS (0.44) | FLT3NRASCDK7CCNHPDGFRB | |
| SCHEMBL27331054 | 0.86 | NRAS (0.39) | FLT3NRAS | |
| SCHEMBL27327102 | 0.86 | NRAS (0.39) | FLT3NRAS | |
| SCHEMBL31739687 | 0.85 | NRAS (0.51) | FLT3NRASCDK7CCNHMNAT1 | |
| SCHEMBL30698306 | 0.83 | PIK3CD (0.37) | FLT3NRAS | |
| SCHEMBL24542246 | 0.82 | NRAS (0.56) | FLT3NRASCDK7CCNHMNAT1 | |
| SCHEMBL27198198 | 0.82 | NRAS (0.56) | FLT3NRASCDK7CCNHMNAT1 | |
| SCHEMBL31740008 | 0.82 | NRAS (0.55) | FLT3NRASCDK7CCNHMNAT1 | |
| SCHEMBL27330375 | 0.82 | NRAS (0.55) | FLT3NRASCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540248-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023245123-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-12-21 | — | — | WO | disclosed |