Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dovramilast. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B known ✓ | Q07343 | 20/20 | 0.59 |
| ▸ | PDE4C known ✓ | Q08493 | 18/20 | 0.59 |
| ▸ | PDE4A known ✓ | P27815 | 12/20 | 0.59 |
| ▸ | PDE4D known ✓ | Q08499 | 12/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dovramilast SCHEMBL673303 | 1.00 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL15869364 | 1.00 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL827461 | 1.00 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL14983202 | 1.00 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL29366888 | 1.00 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL15869363 | 1.00 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL15869345 | 0.95 | PDE4B (0.53) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL15869344 | 0.95 | PDE4B (0.53) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL15580958 | 0.95 | PDE4B (0.53) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL15869347 | 0.94 | PDE4B (0.56) | PDE4BPDE4CPDE4APDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023245000-A2 | METHODS FOR PROCESSING, ENRICHMENT, DELIVERY, FORMULATION, UPTAKE AND TESTING FOR SUPPLEMENTS AND PHARMACEUTICALS | VAN DE CASTEELE RUSSELL (US) | 2023-12-21 | — | — | WO | claimed |
| WO-2023245000-A2 | METHODS FOR PROCESSING, ENRICHMENT, DELIVERY, FORMULATION, UPTAKE AND TESTING FOR SUPPLEMENTS AND PHARMACEUTICALS | VAN DE CASTEELE RUSSELL (US) | 2023-12-21 | — | — | WO | disclosed |