Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.65 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21062069 | 1.00 | PDE4D (0.65) | PDE4DNAPEPLDBRD4PIK3CAPDE10A | |
| SCHEMBL21061347 | 0.81 | PDE4D (0.46) | PDE4DNAPEPLDPIK3CAPDE10AALDH1A1 | |
| SCHEMBL23088619 | 0.78 | PDE4D (0.62) | PDE4DNAPEPLDBRD4PIK3CAPDE10A | |
| SCHEMBL23088621 | 0.78 | PDE4D (0.62) | PDE4DNAPEPLDBRD4PIK3CAPDE10A | |
| SCHEMBL30712004 | 0.78 | PDE4D (0.62) | PDE4DNAPEPLDBRD4PIK3CAPDE10A | |
| SCHEMBL21062072 | 0.76 | PDE4D (0.39) | PDE4DPDE10AALDH1A1TSHRMAPK1 | |
| SCHEMBL30712011 | 0.76 | PDE4D (0.39) | PDE4DPDE10AALDH1A1TSHRMAPK1 | |
| SCHEMBL23088624 | 0.69 | PDE4D (0.64) | PDE4DPDE10AALDH1A1MAPK1HRH4 | |
| SCHEMBL23088623 | 0.69 | PDE4D (0.64) | PDE4DPDE10AALDH1A1MAPK1HRH4 | |
| SCHEMBL30712005 | 0.69 | PDE4D (0.64) | PDE4DPDE10AALDH1A1MAPK1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111727191-B | Substituted azetidine dihydro-thienopyridines and their use as phosphodiesterase inhibitors | 联合疗法公司 | 2024-01-05 | — | — | CN | disclosed |