SCHEMBL30713626

SCHEMBL30713626

C[C@@H](Oc1cc2c(-c3cnc(F)c(F)c3)nn(C3CCCCO3)c2cc1F)c1c(Cl)cncc1Cl

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 2/20 0.34
CYP4A11 Q02928 2/20 0.34
KDR P35968 3/20 0.34
ETV6 P41212 3/20 0.34
RET P07949 1/20 0.34
MET P08581 4/20 0.33
ATR Q13535 5/20 0.32
JAK2 O60674 2/20 0.32
INPPL1 O15357 1/20 0.32
DGAT2 Q96PD7 1/20 0.31
INSR P06213 1/20 0.30
NPM1 P06748 1/20 0.30
ALK Q9UM73 1/20 0.30
FLT3 P36888 1/20 0.30
SYK P43405 1/20 0.30
AURKB Q96GD4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30713474 0.88 KDR (0.42) CYP4F2CYP4A11KDRETV6JAK2
SCHEMBL31536713 0.88 CYP4F2 (0.35) CYP4F2CYP4A11KDRETV6RET
SCHEMBL31484973 0.87 RET (0.35) CYP4F2CYP4A11KDRETV6RET
SCHEMBL30713519 0.85 FGFR4 (0.34) KDRETV6RETATR
SCHEMBL29092373 0.85 CYP4F2 (0.33) CYP4F2CYP4A11KDRETV6RET
SCHEMBL27187897 0.85 CYP4F2 (0.33) CYP4F2CYP4A11KDRETV6RET
SCHEMBL27187892 0.85 CYP4F2 (0.33) CYP4F2CYP4A11KDRETV6RET
SCHEMBL30713495 0.84 KDR (0.35) KDRETV6METATRJAK2
SCHEMBL30713473 0.84 FGFR4 (0.32) KDRRETMETJAK2DGAT2
SCHEMBL30178225 0.82 KDR (0.41) CYP4F2CYP4A11KDRETV6JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250368666-A1 INDAZOLE COMPOUNDS TYRA BIOSCIENCES INC (US) 2025-12-04 US disclosed
EP-4547656-A1 INDAZOLE COMPOUNDS Tyra Biosciences, Inc. (US) 2025-05-07 EP disclosed
CN-119731165-A Indazole compounds 泰拉生物科学公司 2025-03-28 CN disclosed
WO-2024006897-A1 INDAZOLE COMPOUNDS TYRA BIOSCIENCES, INC. (US) 2024-01-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250368666-A1 INDAZOLE COMPOUNDS FGFR1, FGFR3, FGFR2 CYP4F2 1319/4885CYP4A11 933/4885KDR 156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.