SCHEMBL30713709

SCHEMBL30713709

CNC(=O)COc1cc2cc(Nc3nc(N4CCC(C(=O)NC)CC4)ncc3Cl)cc(OC)c2n(C)c1=O

nearest known ligand 0.85

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
BCL6 P41182 19/20 0.85
CHRM4 P08173 1/20 0.85
BCL6B Q8N143 1/20 0.85
MELK Q14680 1/20 0.57
NCOR2 Q9Y618 4/20 0.56
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22932325 0.95 BCL6 (0.86) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL20284550 0.94 BCL6 (0.85) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL20284171 0.93 BCL6 (0.83) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL29508710 0.92 BCL6 (1.00) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL20284237 0.92 BCL6 (1.00) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL25228543 0.92 BCL6 (0.82) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL30486070 0.92 BCL6 (0.82) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL24410970 0.90 BCL6 (0.74) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL25223209 0.90 BCL6 (0.79) BCL6CHRM4BCL6BMELKNCOR2
SCHEMBL24410962 0.89 BCL6 (0.73) BCL6CHRM4BCL6BMELKNCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119486762-A Compositions, systems, and methods for modulating a target gene 小利兰·斯坦福大学托管委员会 2025-02-18 CN disclosed
CN-117120096-A Regulation of gene expression via transcription factor-chemical induction proximity (TF-CIP) 小利兰·斯坦福大学托管委员会 2023-11-24 CN disclosed