Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Selonsertib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 known ✓ | Q99683 | 20/20 | 0.90 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Selonsertib SCHEMBL17873148 | 0.97 | MAP3K5 (0.89) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873177 | 0.96 | MAP3K5 (0.94) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873147 | 0.96 | MAP3K5 (0.94) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL29977277 | 0.95 | MAP3K5 (1.00) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL14672984 | 0.95 | MAP3K5 (1.00) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873132 | 0.94 | MAP3K5 (0.98) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873174 | 0.93 | MAP3K5 (0.96) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873192 | 0.93 | MAP3K5 (0.87) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873149 | 0.92 | MAP3K5 (0.92) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873198 | 0.92 | MAP3K5 (0.92) | MAP3K5MAP3K6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4265250-A2 | SOLID FORMS OF AN ASK1 INHIBITOR | Gilead Sciences, Inc. (US) | 2023-10-25 | — | — | EP | claimed |
| EP-4265250-A2 | SOLID FORMS OF AN ASK1 INHIBITOR | Gilead Sciences, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |