SCHEMBL30714722

SCHEMBL30714722

Cn1nc2ccc(OCc3cccnc3C(F)(F)F)cc2c1C(=O)O

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 3/20 0.39
MAPT P10636 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
MEN1 O00255 1/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
HTT P42858 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
PPARG P37231 5/20 0.37
OPRL1 P41146 1/20 0.37
SLC26A4 O43511 1/20 0.36
GRM2 Q14416 1/20 0.36
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
ELANE P08246 1/20 0.35
PPARD Q03181 3/20 0.35
PPARA Q07869 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26696047 1.00 KDM4C (0.39) KDM4CMAPTL3MBTL1MEN1LMNA
SCHEMBL26696085 0.90 NPC1 (0.37) KDM4CMAPTL3MBTL1MEN1LMNA
SCHEMBL30714557 0.90 NPC1 (0.37) KDM4CMAPTL3MBTL1MEN1LMNA
SCHEMBL30714582 0.86 CNR2 (0.37) OPRL1
SCHEMBL30714749 0.86 OPRL1 (0.35) KDM4CMAPTL3MBTL1MEN1LMNA
SCHEMBL30714553 0.84 GCK (0.41) OPRL1
SCHEMBL30714600 0.84 TYK2 (0.38) MAPTOPRL1GRM2
SCHEMBL30714680 0.83 SCN9A (0.38) OPRL1GRM2
SCHEMBL30714598 0.83 OPRL1 (0.35) KDM4COPRL1GRM2MAOB
SCHEMBL30714729 0.83 OPRL1 (0.35) L3MBTL1OPRL1GRM2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119968362-A Indazole derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-05-09 CN disclosed
EP-4499624-A2 INDAZOLE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-02-05 EP disclosed
WO-2023230540-A2 INDAZOLE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO disclosed