Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25304142 | 1.00 | AURKA (0.47) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| Iodide SCHEMBL26981826 | 0.98 | AURKA (0.46) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL22864675 | 0.82 | PDPK1 (0.52) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL17883509 | 0.81 | JAK2 (0.47) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| Iodide SCHEMBL17873364 | 0.80 | JAK2 (0.46) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL21618384 | 0.79 | AURKA (0.50) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL26389859 | 0.79 | DYRK1A (0.50) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL857144 | 0.78 | AURKA (0.47) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL30068918 | 0.78 | AURKA (0.47) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL23087743 | 0.78 | KDR (0.47) | AURKAJAK2MAP4K4FGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4303216-A1 | FUSED RING SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2024-01-10 | — | — | EP | disclosed |