Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.79 |
| ▸ | GAA | P10253 | 3/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.63 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.61 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.57 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9231347 | 1.00 | NPSR1 (0.79) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL22721524 | 0.85 | NPSR1 (0.67) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4722433 | 0.85 | NPSR1 (0.64) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL29539897 | 0.85 | NPSR1 (0.67) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL28931888 | 0.85 | NPSR1 (0.60) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL24000702 | 0.85 | NPSR1 (0.68) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL9225993 | 0.83 | NPSR1 (0.82) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL29539654 | 0.83 | NPSR1 (0.64) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL22721744 | 0.83 | NPSR1 (0.64) | NPSR1GAAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL9229195 | 0.82 | NPSR1 (1.00) | NPSR1GAAALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |