Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496942 | 1.00 | ATM (0.59) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL28988471 | 0.85 | ATM (0.61) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL27348252 | 0.78 | ATM (0.49) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL30954305 | 0.78 | ATM (0.49) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL2230907 | 0.78 | ATM (0.61) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL14124174 | 0.77 | ROCK1 (0.56) | ATMNPSR1ROCK1KDM4EALDH1A1 | |
| SCHEMBL14124179 | 0.77 | ATM (0.64) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL14124148 | 0.77 | NPSR1 (0.51) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL29360632 | 0.77 | ATM (0.64) | ATMNPSR1ROCK1ROCK2KDM4E | |
| SCHEMBL1904310 | 0.76 | ATM (0.73) | ATMNPSR1ROCK1ROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |