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SCHEMBL30720917

SCHEMBL30720917

CC(C)(C)OC(=O)N1C[C@@H]2C(CN3CCN(CC4CCN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)[C@@H]2C1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 14/20 0.55
▸ AR P10275 4/20 0.55
▸ DDB1 Q16531 3/20 0.48
▸ BTK Q06187 3/20 0.47
▸ CDK9 P50750 1/20 0.47
▸ IRAK1 P51617 1/20 0.46
▸ IRAK4 Q9NWZ3 1/20 0.46
▸ IRAK3 Q9Y616 1/20 0.46
▸ ITK Q08881 1/20 0.45
▸ RAF1 P04049 2/20 0.45
▸ ALK Q9UM73 1/20 0.43
▸ PLK4 O00444 1/20 0.42
▸ HPGDS O60760 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29927982 1.00 CRBN (0.55) CRBNARDDB1BTKCDK9
SCHEMBL29132109 0.94 CRBN (0.57) CRBNARDDB1BTKCDK9
SCHEMBL29928196 0.94 CRBN (0.57) CRBNARDDB1BTKCDK9
SCHEMBL20231763 0.92 CRBN (0.59) CRBNARDDB1BTKCDK9
SCHEMBL29927733 0.92 CRBN (0.59) CRBNARDDB1BTKCDK9
SCHEMBL29132140 0.92 CRBN (0.59) CRBNARDDB1BTKCDK9
SCHEMBL29132225 0.92 CRBN (0.57) CRBNARDDB1BTKCDK9
SCHEMBL29927925 0.92 CRBN (0.57) CRBNARDDB1BTKCDK9
SCHEMBL31619110 0.91 CRBN (0.58) CRBNARDDB1BTKCDK9
SCHEMBL20234891 0.91 CRBN (0.58) CRBNARDDB1BTKCDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117321046-A Indazole-based compounds and related methods of use 阿维纳斯企业公司 2023-12-29 — — CN disclosed