Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.35 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.35 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.35 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25830219 | 0.96 | KRAS (0.46) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23137456 | 0.94 | KRAS (0.41) | KRAS | |
| SCHEMBL24692109 | 0.92 | KRAS (0.46) | KRAS | |
| SCHEMBL24692122 | 0.91 | KRAS (0.40) | KRAS | |
| SCHEMBL24692385 | 0.88 | KRAS (0.40) | KRAS | |
| SCHEMBL27149319 | 0.86 | KRAS (0.54) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL24691787 | 0.84 | KRAS (0.60) | KRAS | |
| SCHEMBL24692398 | 0.84 | KRAS (0.40) | KRAS | |
| SCHEMBL29907484 | 0.83 | KRAS (0.47) | KRAS | |
| SCHEMBL23300813 | 0.82 | KRAS (0.50) | KRASEGFRHMOX2CRYZVAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4053118-B1 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | GENFLEET THERAPEUTICS SHANGHAI INC (CN) | 2024-10-09 | — | — | EP | disclosed |
| EP-4328229-A2 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2024-02-28 | — | — | EP | disclosed |