Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | IDO1 | P14902 | 4/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.56 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.56 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TTK | P33981 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30725855 | 1.00 | MAPT (0.68) | MAPTHPGDIDO1AURKAMAPK1 | |
| SCHEMBL5378145 | 0.88 | MAPT (0.81) | MAPTHPGDIDO1AURKALMNA | |
| SCHEMBL20380220 | 0.83 | HPGD (0.68) | MAPTHPGDIDO1AURKAMAPK1 | |
| SCHEMBL5375082 | 0.82 | MAPT (0.84) | MAPTHPGDIDO1AURKAMAPK1 | |
| SCHEMBL4007995 | 0.81 | MAPT (1.00) | MAPTHPGDIDO1ALDH1A1TTK | |
| SCHEMBL1513036 | 0.81 | MAPT (0.78) | MAPTHPGDIDO1MAP2K4ALDH1A1 | |
| SCHEMBL9468491 | 0.80 | MAPT (0.57) | MAPTHPGDIDO1AURKAMAPK1 | |
| SCHEMBL5377226 | 0.78 | MAPT (0.94) | MAPTHPGDIDO1ALDH1A1TTK | |
| SCHEMBL2860859 | 0.78 | MAP2K7 (0.59) | MAPTHPGDMAPK1MAP2K4MAPK6 | |
| SCHEMBL7366219 | 0.76 | PDE4D (0.58) | MAPTHPGDIDO1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117186066-A | Indazole ALK5 inhibitor and preparation method and application thereof | 中国药科大学 | 2023-12-08 | — | — | CN | disclosed |