Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.56 |
| ▸ | CCND1 | P24385 | 13/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 12/20 | 0.56 |
| ▸ | CDK4 | P11802 | 9/20 | 0.56 |
| ▸ | CDK9 | P50750 | 7/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | CASK | O14936 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | CDK14 | O94921 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033385 | 1.00 | CDK2 (0.56) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL27063563 | 0.83 | EGFR (0.40) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL30726201 | 0.82 | CDK2 (0.55) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL27033299 | 0.82 | CDK2 (0.55) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL29754906 | 0.78 | CDK2 (0.60) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL30768098 | 0.77 | CCNE1 (0.56) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL27034859 | 0.77 | CCNE1 (0.56) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL27358142 | 0.77 | CDK2 (0.53) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL5002277 | 0.76 | CCNE1 (0.56) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL29594774 | 0.76 | CDK2 (0.56) | CDK2CCNE1CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558493-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE | Iambic Therapeutics, Inc. (US) | 2025-05-28 | — | — | EP | disclosed |
| CN-119894880-A | Quinazoline compounds and methods of use | 依安彼克医疗有限公司 | 2025-04-25 | — | — | CN | disclosed |
| WO-2024020380-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE | IAMBIC THERAPEUTICS, INC. (US) | 2024-01-25 | — | — | WO | disclosed |