SCHEMBL30727366

SCHEMBL30727366

COC(=O)c1cc2sc(N)nc2cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
NPC1 O15118 1/20 0.51
MAPT P10636 1/20 0.51
RAB9A P51151 1/20 0.51
KMT2A Q03164 1/20 0.51
CYP3A4 P08684 4/20 0.46
CYP2C9 P11712 2/20 0.46
KCNH2 Q12809 1/20 0.46
PKM P14618 2/20 0.46
RCE1 Q9Y256 1/20 0.46
CYP1A2 P05177 2/20 0.46
ALDH1A1 P00352 3/20 0.45
TP53 P04637 1/20 0.45
TSHR P16473 1/20 0.45
NQO2 P16083 5/20 0.45
EPHX2 P34913 1/20 0.44
ILK Q13418 1/20 0.44
CYP2C19 P33261 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6058371 1.00 KDM4E (0.51) KDM4ESMN1; SMN2NPC1MAPTRAB9A
SCHEMBL23858344 0.84 CYP3A4 (0.58) KDM4ESMN1; SMN2NPC1MAPTRAB9A
SCHEMBL2913039 0.83 GAA (0.49) KDM4ESMN1; SMN2NPC1MAPTRAB9A
SCHEMBL6058046 0.80 CYP3A4 (0.46) KDM4ESMN1; SMN2NPC1MAPTRAB9A
SCHEMBL23629051 0.80 CYP3A4 (0.44) KDM4ESMN1; SMN2NPC1MAPTRAB9A
SCHEMBL30697742 0.78 NPC1 (0.48) KDM4ESMN1; SMN2NPC1MAPTRAB9A
SCHEMBL29741763 0.77 CYP3A4 (0.53) SMN1; SMN2NPC1MAPTRAB9AKMT2A
SCHEMBL7679151 0.77 CYP3A4 (0.53) SMN1; SMN2NPC1MAPTRAB9AKMT2A
SCHEMBL27268257 0.77 KDM4E (0.43) KDM4ESMN1; SMN2NPC1MAPTRAB9A
SCHEMBL30727226 0.77 PIK3CA (0.49) SMN1; SMN2NPC1MAPTRAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4547671-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2025-05-07 EP disclosed
CN-119255997-A Modulators of c-MYC mRNA translation and their use in the treatment of cancer 艾尼莫生物科技公司 2025-01-03 CN disclosed
WO-2024010761-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 WO disclosed