Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27179161 | 1.00 | PPM1D (0.32) | PPM1D | |
| SCHEMBL27274686 | 0.86 | MAPT (0.35) | PPM1D | |
| SCHEMBL27179170 | 0.86 | MAPT (0.35) | PPM1D | |
| SCHEMBL31234770 | 0.86 | MAPT (0.35) | PPM1D | |
| SCHEMBL22367426 | 0.86 | DPP4 (0.39) | PPM1D | |
| SCHEMBL5183988 | 0.85 | HSD17B10 (0.33) | — | |
| SCHEMBL5120279 | 0.85 | HSD17B10 (0.33) | — | |
| SCHEMBL31234561 | 0.85 | HSD17B10 (0.33) | — | |
| SCHEMBL30861987 | 0.85 | HSD17B10 (0.33) | — | |
| SCHEMBL31234179 | 0.83 | PPM1D (0.31) | PPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220532-A1 | PYRROLIDINE KRAS INHIBITORS | INCYTE CORPORATION (US) | 2024-10-24 | — | — | WO | disclosed |
| WO-2024015731-A1 | FUSED TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS G12V MUTANTS | INCYTE CORPORATION (US) | 2024-01-18 | — | — | WO | disclosed |