Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 9/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.45 |
| ▸ | SGK1 | O00141 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | FES | P07332 | 2/20 | 0.39 |
| ▸ | ROS1 | P08922 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.39 |
| ▸ | FER | P16591 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22554109 | 1.00 | AXL (0.45) | AXLCAMKK2SGK1POLBHCAR2 | |
| SCHEMBL22554203 | 0.85 | SGK1 (0.45) | AXLCAMKK2SGK1DYRK1ACLK1 | |
| SCHEMBL30731143 | 0.85 | SGK1 (0.45) | AXLCAMKK2SGK1DYRK1ACLK1 | |
| SCHEMBL20780050 | 0.83 | AXL (0.47) | AXLCAMKK2SGK1MAPK1 | |
| SCHEMBL30731267 | 0.83 | DYRK1A (0.47) | AXLDYRK1ACLK1DYRK1BROCK2 | |
| SCHEMBL22554153 | 0.83 | DYRK1A (0.47) | AXLDYRK1ACLK1DYRK1BROCK2 | |
| SCHEMBL30504208 | 0.83 | AXL (0.47) | AXLCAMKK2SGK1MAPK1 | |
| SCHEMBL22554074 | 0.81 | MAP4K1 (0.48) | AXLDYRK1ACLK1DYRK1BIGF1R | |
| SCHEMBL30731147 | 0.81 | MAP4K1 (0.48) | AXLDYRK1ACLK1DYRK1BIGF1R | |
| SCHEMBL2671287 | 0.80 | AXL (0.45) | AXLCAMKK2SGK1HCAR2ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |