Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19389997 | 0.92 | NR1H2 (0.59) | NR1H2JAK2JAK1GPR119HPGD | |
| SCHEMBL39998 | 0.91 | JAK2 (0.50) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL29913770 | 0.91 | JAK2 (0.50) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL27427012 | 0.91 | NR1H2 (0.52) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL43022 | 0.91 | JAK2 (0.50) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL24740662 | 0.89 | NR1H2 (0.68) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL20936763 | 0.89 | NR1H2 (0.68) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL20566533 | 0.89 | NR1H2 (0.68) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL20936755 | 0.89 | NR1H2 (0.68) | NR1H2JAK2JAK1CHRM2CHRM1 | |
| SCHEMBL4409452 | 0.89 | NR1H2 (0.68) | NR1H2JAK2JAK1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117377675-A | Bruton's tyrosine kinase degradation agent containing parallel ring or spiro ring | 正大天晴药业集团股份有限公司 | 2024-01-09 | — | — | CN | disclosed |