Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.63 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.63 |
| ▸ | IKZF2 | Q9UKS7 | 6/20 | 0.38 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.38 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25934694 | 1.00 | CRBN (0.63) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL21997980 | 0.92 | CRBN (0.68) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL26635224 | 0.91 | CRBN (0.61) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL26634854 | 0.91 | CRBN (0.61) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL23832553 | 0.90 | CRBN (0.60) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL26634926 | 0.89 | CRBN (0.61) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL26635073 | 0.89 | CRBN (0.61) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL24764683 | 0.88 | CRBN (0.70) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL31701052 | 0.88 | CRBN (0.60) | CRBNDDB1IKZF2IKZF3IKZF1 | |
| SCHEMBL24269425 | 0.87 | CRBN (0.70) | CRBNDDB1IKZF2IKZF3IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519273-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023215906-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | HANGZHOU JIJING PHARMACEUTICALTECHNOLOGY LIMITED (CN) | 2023-11-09 | — | — | WO | disclosed |