Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 14/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27166564 | 1.00 | CRBN (0.52) | CRBNDDB1STAT3TRIM24JAK2 | |
| SCHEMBL26099885 | 1.00 | CRBN (0.52) | CRBNDDB1STAT3TRIM24JAK2 | |
| SCHEMBL26635204 | 0.99 | CRBN (0.53) | CRBNDDB1STAT3TRIM24CSNK1A1 | |
| SCHEMBL30733853 | 0.96 | CRBN (0.53) | CRBNDDB1CSNK1A1IKZF1 | |
| SCHEMBL25123021 | 0.91 | DDB1 (0.50) | CRBNDDB1STAT3TRIM24HDAC8 | |
| SCHEMBL25123067 | 0.91 | CRBN (0.49) | CRBNDDB1STAT3TRIM24JAK2 | |
| SCHEMBL25122764 | 0.91 | CRBN (0.49) | CRBNDDB1STAT3TRIM24JAK2 | |
| SCHEMBL25123841 | 0.88 | DDB1 (0.51) | CRBNDDB1 | |
| SCHEMBL25123845 | 0.88 | DDB1 (0.51) | CRBNDDB1 | |
| SCHEMBL23842178 | 0.88 | DDB1 (0.51) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731309-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| EP-4519273-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2024263586-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | PAQ Therapeutics Inc. (US) | 2024-12-26 | — | — | WO | disclosed |
| WO-2023215906-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | HANGZHOU JIJING PHARMACEUTICALTECHNOLOGY LIMITED (CN) | 2023-11-09 | — | — | WO | disclosed |