Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326590 | 0.91 | KDM4E (0.66) | KDM4EHRH3MEN1ALDH1A1KMT2A | |
| SCHEMBL25059606 | 0.87 | KDM4E (0.67) | KDM4EL3MBTL1HRH3KCNH2ACHE | |
| SCHEMBL26636800 | 0.86 | HRH3 (0.53) | KDM4EL3MBTL1HRH3HRH1MEN1 | |
| SCHEMBL14419243 | 0.84 | KDM4E (0.59) | KDM4EL3MBTL1HRH3KCNH2MAOB | |
| SCHEMBL1776035 | 0.83 | HRH3 (0.62) | KDM4EL3MBTL1HRH3ATMKCNH2 | |
| SCHEMBL3573539 | 0.83 | HRH3 (0.59) | KDM4EL3MBTL1HRH3ATMKCNH2 | |
| SCHEMBL3581300 | 0.83 | KDM4E (0.64) | KDM4EL3MBTL1HRH3ATMACHE | |
| SCHEMBL6035058 | 0.81 | MEN1 (0.55) | KDM4EHRH3MAOBMEN1ALDH1A1 | |
| SCHEMBL10800418 | 0.80 | MAOB (0.61) | KDM4EL3MBTL1HRH3ATMKCNH2 | |
| SCHEMBL3585716 | 0.80 | HRH3 (0.55) | KDM4EL3MBTL1HRH3ATMKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519259-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023215482-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |