Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK14 | O94921 | 6/20 | 0.45 |
| ▸ | CCNY | Q8ND76 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27129983 | 1.00 | CDK14 (0.45) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26986517 | 1.00 | CDK14 (0.45) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27084621 | 0.87 | IRAK1 (0.48) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30279687 | 0.87 | IRAK1 (0.48) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23860733 | 0.87 | IRAK1 (0.48) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23860729 | 0.87 | IRAK1 (0.48) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30165298 | 0.87 | IRAK1 (0.48) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26986619 | 0.87 | TP53 (0.39) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26986482 | 0.86 | TP53 (0.38) | CDK14CCNYNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26986488 | 0.85 | CDK14 (0.37) | CDK14CCNYNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4551218-A2 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | Dana-Farber Cancer Institute, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024011116-A2 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-01-11 | — | — | WO | disclosed |