SCHEMBL30736992

SCHEMBL30736992

COC(=O)c1cc(Nc2ncc(F)cc2F)c(-c2cn(C)c(=O)c3c2ccn3S(=O)(=O)c2ccc(C)cc2)cc1CS(C)(=O)=O

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 17/20 0.43
▸ MAPK14 Q16539 1/20 0.33
▸ ALOX5 P09917 1/20 0.31
▸ PIK3C3 Q8NEB9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22367472 1.00 BRD4 (0.43) BRD4MAPK14ALOX5PIK3C3
SCHEMBL21810740 0.93 BRD4 (0.44) BRD4PIK3C3
SCHEMBL17492759 0.85 BRD4 (0.48) BRD4MAPK14
SCHEMBL29223379 0.84 BRD4 (0.43) BRD4MAPK14PIK3C3
SCHEMBL23647192 0.83 BRD4 (0.51) BRD4ALOX5PIK3C3
SCHEMBL30736961 0.83 BRD4 (0.51) BRD4ALOX5PIK3C3
SCHEMBL22367539 0.82 BRD4 (0.51) BRD4
SCHEMBL17492582 0.76 BRD4 (0.49) BRD4
SCHEMBL17492632 0.75 BRD4 (0.51) BRD4
SCHEMBL21847421 0.75 BRD4 (0.48) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4580405-A1 COMPOSITIONS AND METHODS FOR TARGETED INHIBITION AND DEGRADATION OF PROTEINS IN AN INSECT CELL Oerth Bio LLC (US) 2025-07-09 — — EP disclosed
WO-2024050016-A9 COMPOSITIONS AND METHODS FOR TARGETED INHIBITION AND DEGRADATION OF PROTEINS IN AN INSECT CELL OERTH BIO LLC (US) 2025-04-03 — — WO disclosed
WO-2025049555-A1 COMPOSITIONS AND METHODS FOR TARGETED INHIBITION AND DEGRADATION OF PROTEINS IN AN INSECT CELL OERTH BIO LLC (US) 2025-03-06 — — WO disclosed
WO-2024050016-A1 COMPOSITIONS AND METHODS FOR TARGETED INHIBITION AND DEGRADATION OF PROTEINS IN AN INSECT CELL OERTH BIO LLC (US) 2024-03-07 — — WO disclosed
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