Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lucitanib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 20/20 | 1.00 |
| ▸ | FLT1 known ✓ | P17948 | 3/20 | 1.00 |
| ▸ | FGFR1 known ✓ | P11362 | 2/20 | 1.00 |
| ▸ | FGFR2 known ✓ | P21802 | 2/20 | 1.00 |
| ▸ | FLT4 known ✓ | P35916 | 2/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.98 |
| ▸ | LYN | P07948 | 4/20 | 0.98 |
| ▸ | PDXK | O00764 | 1/20 | 0.98 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.98 |
| ▸ | RET | P07949 | 1/20 | 0.98 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.98 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.98 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.98 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.98 |
| ▸ | AURKA | O14965 | 14/20 | 0.78 |
| ▸ | LCK | P06239 | 14/20 | 0.78 |
| ▸ | TEK | Q02763 | 14/20 | 0.78 |
| ▸ | MET | P08581 | 12/20 | 0.78 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | FGR | P09769 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lucitanib SCHEMBL29379692 | 1.00 | KDR (1.00) | KDRFLT1FGFR1FGFR2FLT4 | |
| Lucitanib SCHEMBL26928177 | 1.00 | KDR (1.00) | KDRFLT1FGFR1FGFR2FLT4 | |
| Lucitanib SCHEMBL29375046 | 0.99 | KDR (1.00) | KDRFLT1FGFR1FGFR2FLT4 | |
| Lucitanib SCHEMBL381394 | 0.99 | KDR (1.00) | KDRFLT1FGFR1FGFR2FLT4 | |
| Lucitanib SCHEMBL29363689 | 0.99 | KDR (1.00) | KDRFLT1FGFR1FGFR2FLT4 | |
| Lucitanib SCHEMBL29365836 | 0.99 | KDR (1.00) | KDRFLT1FGFR1FGFR2FLT4 | |
| SCHEMBL2097763 | 0.90 | KDR (0.83) | KDRFLT1FGFR1FGFR2FLT4 | |
| SCHEMBL2099219 | 0.89 | KDR (0.81) | KDRFLT1FGFR1FGFR2FLT4 | |
| SCHEMBL381963 | 0.89 | KDR (0.81) | KDRFLT1FGFR1FGFR2FLT4 | |
| SCHEMBL2101349 | 0.89 | KDR (0.81) | KDRFLT1FGFR1FGFR2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023240271-A1 | USE OF VEGFR2 AND FGFR1 INHIBITORS IN THERAPY | FOUNTAIN THERAPEUTICS INC. (US) | 2023-12-14 | — | — | WO | claimed |
| WO-2023240271-A1 | USE OF VEGFR2 AND FGFR1 INHIBITORS IN THERAPY | FOUNTAIN THERAPEUTICS INC. (US) | 2023-12-14 | — | — | WO | disclosed |