Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA2 | Q15349 | 10/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089903 | 0.89 | RPS6KA2 (0.44) | RPS6KA2RPS6KA3SRD5A2SRD5A1 | |
| SCHEMBL3084506 | 0.83 | KDM4E (0.44) | RPS6KA2RPS6KA3ALDH1A1AKR1C3POLB | |
| SCHEMBL3093321 | 0.81 | RPS6KA2 (0.38) | RPS6KA2RPS6KA3 | |
| SCHEMBL3092044 | 0.81 | RPS6KA2 (0.43) | RPS6KA2RPS6KA3SRD5A2SRD5A1 | |
| SCHEMBL4144549 | 0.80 | RPS6KA2 (0.42) | RPS6KA2RPS6KA3ALDH1A1AKR1C3POLB | |
| SCHEMBL3574670 | 0.77 | SRD5A2 (0.50) | RPS6KA2RPS6KA3SRD5A2SRD5A1ALDH1A1 | |
| SCHEMBL2430933 | 0.76 | RPS6KA2 (0.37) | RPS6KA2RPS6KA3 | |
| SCHEMBL3080181 | 0.76 | SRD5A2 (0.40) | RPS6KA2RPS6KA3SRD5A2SRD5A1ALDH1A1 | |
| SCHEMBL4144545 | 0.75 | RPS6KA2 (0.36) | RPS6KA2RPS6KA3SRD5A2SRD5A1 | |
| SCHEMBL3080179 | 0.74 | RPS6KA2 (0.54) | RPS6KA2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795247-B2 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-09-14 | — | — | US | disclosed |
| US-20060100262-A1 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICHERCHEDI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IRMB) (IT) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100262-A1 | Tetracyclic indole derivatives as antiviral agents | IDO1, ZC3HAV1, IDO2 | RPS6KA2 2765/4885RPS6KA3 1950/4885SRD5A2 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.