SCHEMBL30739063

SCHEMBL30739063

COCc1ccc(Cn2cc(C(=O)NCc3ccc(C(=N)N)cc3)cn2)cc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ KLKB1 P03952 20/20 0.77
▸ KLK1 P06870 3/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30739119 0.91 KLKB1 (0.76) KLKB1KLK1
SCHEMBL30739101 0.87 KLKB1 (0.83) KLKB1KLK1
SCHEMBL1981938 0.87 KLKB1 (1.00) KLKB1KLK1
Acetic Acid SCHEMBL29253774 0.86 KLKB1 (0.94) KLKB1KLK1
Hydrochloric Acid SCHEMBL1985633 0.86 KLKB1 (0.98) KLKB1KLK1
SCHEMBL30739095 0.86 KLKB1 (0.82) KLKB1KLK1
SCHEMBL30739034 0.85 KLKB1 (0.84) KLKB1KLK1
SCHEMBL30739084 0.84 KLKB1 (0.76) KLKB1KLK1
SCHEMBL30739045 0.84 KLKB1 (0.72) KLKB1KLK1
SCHEMBL16365808 0.83 KLKB1 (0.80) KLKB1KLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4561993-A1 INHIBITORS OF PLASMA KALLIKREIN Rezolute, Inc. (US) 2025-06-04 — — EP disclosed
WO-2024025907-A1 INHIBITORS OF PLASMA KALLIKREIN REZOLUTE, INC. (US) 2024-02-01 — — WO disclosed
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