Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21225577 | 1.00 | RHEB (0.56) | RHEBL3MBTL1RAB9AHSD11B1MAPT | |
| SCHEMBL23709588 | 0.84 | RHEB (0.67) | RHEBL3MBTL1HSD11B1MAPTLMNA | |
| SCHEMBL1137574 | 0.80 | RHEB (0.56) | RHEBHSD11B1MAPTLMNANPSR1 | |
| SCHEMBL7964114 | 0.79 | RHEB (0.77) | RHEBHSD11B1MAPTNR1H2NR1H3 | |
| SCHEMBL1138102 | 0.77 | RHEB (0.64) | RHEBMAPTLMNASLC6A4HTR2A | |
| SCHEMBL1137550 | 0.75 | RHEB (0.57) | RHEBMAPTLMNA | |
| SCHEMBL23709599 | 0.75 | RHEB (0.61) | RHEBMAPTSLC6A4HTR2A | |
| SCHEMBL23408944 | 0.74 | RHEB (0.47) | RHEBL3MBTL1HSD11B1SLC6A4NR1H2 | |
| SCHEMBL1138270 | 0.73 | RHEB (0.52) | RHEBHSD11B1SLC6A4HTR2AKCNH2 | |
| SCHEMBL1137699 | 0.73 | RHEB (0.59) | RHEBHSD11B1MAPTSLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936138-B | Heterobicyclic compounds as EP4 receptor antagonists | 深圳市原力生命科学有限公司 | 2024-03-08 | — | — | CN | disclosed |