Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26984970 | 1.00 | RAF1 (0.41) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL26984926 | 0.89 | RAF1 (0.43) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL30746450 | 0.89 | RAF1 (0.43) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL26984961 | 0.88 | RAF1 (0.42) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL26985095 | 0.88 | RAF1 (0.42) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL30746420 | 0.88 | RAF1 (0.42) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL30746529 | 0.88 | RAF1 (0.42) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL26994668 | 0.87 | RAF1 (0.44) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL30746504 | 0.87 | MAP2K1 (0.41) | RAF1MAP2K1CYP2C9BRAFMAP2K2 | |
| SCHEMBL26984993 | 0.87 | MAP2K1 (0.41) | RAF1MAP2K1CYP2C9BRAFMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4551558-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | Nested Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |