Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24046445 | 1.00 | CRBN (0.63) | CRBNESR1 | |
| SCHEMBL30646886 | 1.00 | CRBN (0.63) | CRBNESR1 | |
| SCHEMBL29614668 | 1.00 | CRBN (0.63) | CRBNESR1 | |
| SCHEMBL26649398 | 1.00 | CRBN (0.63) | CRBNESR1 | |
| SCHEMBL26658534 | 1.00 | CRBN (0.63) | CRBNESR1 | |
| SCHEMBL26658634 | 0.94 | CRBN (0.61) | CRBN | |
| SCHEMBL30646867 | 0.94 | CRBN (0.61) | CRBN | |
| SCHEMBL26658628 | 0.94 | CRBN (0.61) | CRBN | |
| SCHEMBL20234982 | 0.92 | CRBN (0.63) | CRBNESR1 | |
| SCHEMBL29614522 | 0.92 | CRBN (0.63) | CRBNESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522621-A1 | 6,6A,7,8,9,10-HEXAHYDRO-5H-PYRAZINO[1',2':4,5]PYRAZINO[2,3-C]PYRIDAZINE DERIVATIVES AS SMARCA4 PROTEIN DEGRADERS FOR THE TREATMENT OF CANCER | Prelude Therapeutics Incorporated (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220577-A1 | 6,6A,7,8,9,10-HEXAHYDRO-5H-PYRAZINO[1',2':4,5]PYRAZINO[2,3-C]PYRIDAZINE DERIVATIVES AS SMARCA4 PROTEIN DEGRADERS FOR THE TREATMENT OF CANCER | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2023-11-16 | — | — | WO | disclosed |