Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 2/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.31 |
| ▸ | RXRA | P19793 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628910 | 0.90 | GRIN2B (0.38) | DDB1CRBNMAPK1GRIN2BGRIN2C | |
| SCHEMBL4485043 | 0.87 | GRIN2B (0.39) | DDB1CRBNGRIN2BGRIN2CJAK3 | |
| SCHEMBL4486810 | 0.86 | JAK3 (0.41) | DDB1CRBNGRIN2BGRIN2CJAK3 | |
| SCHEMBL3706160 | 0.81 | JAK3 (0.38) | MAPK1GRIN2BGRIN2CJAK3PARP1 | |
| SCHEMBL26916200 | 0.81 | GRIN2B (0.43) | DDB1CRBNGRIN2BGRIN2CJAK3 | |
| SCHEMBL700241 | 0.79 | JAK3 (0.43) | GRIN2BGRIN2CJAK3SPRUSP2 | |
| SCHEMBL26825330 | 0.78 | GRIN2B (0.39) | DDB1CRBNGRIN2BGRIN2CJAK3 | |
| SCHEMBL15286428 | 0.77 | JAK3 (0.46) | GRIN2BGRIN2CJAK3SPRUSP2 | |
| Hydrochloric Acid SCHEMBL19582520 | 0.77 | JAK3 (0.43) | GRIN2BGRIN2CJAK3SPRUSP2 | |
| SCHEMBL2796099 | 0.77 | BUB1 (0.39) | DDB1CRBNMAPK1GRIN2BGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538072-B | Aminopyrimidine EGFR inhibitors | 齐鲁制药有限公司 | 2024-02-06 | — | — | CN | disclosed |