Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12596669 | 0.76 | KDM4E (0.36) | KDM4EMAOAPOLBSMN1; SMN2CLK1 | |
| SCHEMBL1641167 | 0.76 | KDM4E (1.00) | KDM4EPDGFRBPDGFRAPOLBSMN1; SMN2 | |
| SCHEMBL30315534 | 0.76 | KDM4E (1.00) | KDM4EPDGFRBPDGFRAPOLBSMN1; SMN2 | |
| SCHEMBL23797441 | 0.74 | CLK1 (0.42) | KDM4EMAOAPDE2APDE10APDGFRB | |
| SCHEMBL587832 | 0.73 | MAPT (0.42) | KDM4EMAOAPDGFRBPDGFRACYP11B1 | |
| SCHEMBL30738170 | 0.72 | PDGFRB (0.51) | KDM4EMAOAPDGFRBPDGFRACYP11B1 | |
| SCHEMBL21481133 | 0.72 | LATS1 (0.35) | KDM4ESMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL30711598 | 0.72 | LATS1 (0.38) | MAOAMAPT | |
| SCHEMBL23779278 | 0.72 | KDM4E (0.59) | KDM4EALDH1A1HTTCYP1A2CYP2C19 | |
| SCHEMBL12940648 | 0.72 | LATS1 (0.36) | KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217230-A1 | KINESIN KIF18A INHIBITOR AND USE THEREOF | 上海湃隆生物科技有限公司 | 2023-11-16 | — | — | WO | disclosed |