Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 8/20 | 0.53 |
| ▸ | TACR1 | P25103 | 5/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580868 | 1.00 | PLG (0.53) | PLGTACR1PSEN1PSEN2APH1B | |
| SCHEMBL3078637 | 1.00 | PLG (0.53) | PLGTACR1PSEN1PSEN2APH1B | |
| SCHEMBL587279 | 1.00 | PLG (0.53) | PLGTACR1PSEN1PSEN2APH1B | |
| SCHEMBL3068771 | 1.00 | PLG (0.53) | PLGTACR1PSEN1PSEN2APH1B | |
| SCHEMBL3075070 | 0.90 | PLG (0.54) | PLGTACR1PSEN1PSEN2APH1B | |
| SCHEMBL581412 | 0.90 | PLG (0.54) | PLGTACR1PSEN1PSEN2APH1B | |
| SCHEMBL581576 | 0.90 | PLG (0.54) | PLGTACR1PSEN1PSEN2APH1B | |
| SCHEMBL581453 | 0.90 | PLG (0.42) | PLGTACR1 | |
| SCHEMBL581507 | 0.90 | PLG (0.54) | PLG | |
| SCHEMBL3063105 | 0.90 | PLG (0.54) | PLGTACR1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415378-B2 | Isoxazol-3(2H)-one analogs as therapeutic agents | ASTRAZENECA AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | NR4A3, CBR3, OXER1 | PLG 4861/4885TACR1 474/4885PSEN1 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.